A pilot study on subject-based comprehensive steroid profiling: novel biomarkers to detect testosterone misuse in sports.

Détails

ID Serval
serval:BIB_C02993E49482
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A pilot study on subject-based comprehensive steroid profiling: novel biomarkers to detect testosterone misuse in sports.
Périodique
Clinical Endocrinology
Auteur(s)
Van Renterghem P., Van Eenoo P., Sottas P.E., Saugy M., Delbeke F.
ISSN
1365-2265 (Electronic)
ISSN-L
0300-0664
Statut éditorial
Publié
Date de publication
02/2011
Volume
-
Numéro
-
Pages
-
Langue
anglais
Résumé
Context:  Until now, the testosterone/epitestosterone (T/E) ratio is the main marker for detection of testosterone (T) misuse in athletes. As this marker can be influenced by a number of confounding factors, additional steroid profile parameters indicating T misuse can provide substantiating evidence of doping with endogenous steroids. The evaluation of a steroid profile is currently based upon population statistics. Since large inter-individual variations exist, a paradigm shift towards subject-based references is ongoing in doping analysis. Objective:  Proposition of new biomarkers for the detection of testosterone in sports using extensive steroid profiling and an adaptive model based upon Bayesian inference. Subjects:  6 healthy male volunteers were administered with testosterone undecanoate. Population statistics were performed upon steroid profiles from 2014 male Caucasian athletes participating in official sport competition. Design:  An extended search for new biomarkers in a comprehensive steroid profile combined with Bayesian inference techniques as used in the Athlete Biological Passport resulted in a selection of additional biomarkers that may improve detection of testosterone misuse in sports. Results:  Apart from T/E, 4 other steroid ratios (6α-OH-androstenedione/16α-OH-dehydroepiandrostenedione, 4-OH-androstenedione/16α-OH-androstenedione, 7α-OH-testosterone/7β-OH-dehydroepiandrostenedione and dihydrotestosterone/5β-androstane-3α,17β-diol) were identified as sensitive urinary biomarkers for T misuse. These new biomarkers were rated according to relative response, parameter stability, detection time and discriminative power. Conclusion:  Newly selected biomarkers were found suitable for individual referencing within the concept of the Athlete's Biological Passport. The parameters showed improved detection time and discriminative power compared to the T/E ratio. Such biomarkers can support the evidence of doping with small oral doses of testosterone.
Pubmed
Web of science
Création de la notice
06/01/2012 15:15
Dernière modification de la notice
03/03/2018 21:05
Données d'usage