Study of atrial arrhythmias in a computer model based on magnetic resonance images of human atria.

Détails

ID Serval
serval:BIB_C02270BFF7C1
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Study of atrial arrhythmias in a computer model based on magnetic resonance images of human atria.
Périodique
Chaos
Auteur(s)
Virag  N., Jacquemet  V., Henriquez  C. S., Zozor  S., Blanc  O., Vesin  J. M., Pruvot  E., Kappenberger  L.
ISSN
1054-1500
Statut éditorial
Publié
Date de publication
09/2002
Peer-reviewed
Oui
Volume
12
Numéro
3
Pages
754-763
Notes
Journal article --- Old month value: Sep
Résumé
The maintenance of multiple wavelets appears to be a consistent feature of atrial fibrillation (AF). In this paper, we investigate possible mechanisms of initiation and perpetuation of multiple wavelets in a computer model of AF. We developed a simplified model of human atria that uses an ionic-based membrane model and whose geometry is derived from a segmented magnetic resonance imaging data set. The three-dimensional surface has a realistic size and includes obstacles corresponding to the location of major vessels and valves, but it does not take into account anisotropy. The main advantage of this approach is its ability to simulate long duration arrhythmias (up to 40 s). Clinically relevant initiation protocols, such as single-site burst pacing, were used. The dynamics of simulated AF were investigated in models with different action potential durations and restitution properties, controlled by the conductance of the slow inward current in a modified Luo-Rudy model. The simulation studies show that (1) single-site burst pacing protocol can be used to induce wave breaks even in tissue with uniform membrane properties, (2) the restitution-based wave breaks in an atrial model with realistic size and conduction velocities are transient, and (3) a significant reduction in action potential duration (even with apparently flat restitution) increases the duration of AF. (c) 2002 American Institute of Physics.
Pubmed
Web of science
Création de la notice
28/01/2008 11:04
Dernière modification de la notice
03/03/2018 21:05
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