Problem solving in psychopharmacotherapy using pharmacokinetic and pharmacogenetic tests

Détails

ID Serval
serval:BIB_C0085B5111A4
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Problem solving in psychopharmacotherapy using pharmacokinetic and pharmacogenetic tests
Auteur(s)
Baumann Pierre
ISBN
0924-9338
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
21
Série
European Psychiatry
Pages
64
Langue
anglais
Notes
SAPHIRID:62000
Résumé
A widely introduced pharmacokinetic test in psychopharmacotherapy is therapeutic drug monitoring (TDM). It is especially recommended in patients who are non-compliant, who poorly tolerate, or who do not respond to a medication. It is also useful in patients belonging to the category of "special populations", i.e. somatically ill patients, who are comedicated with a variety of drugs and who suffer from a liver or renal disease, as well as in elderly or very young patients. Increasingly, the use of generics has been shown to represent a source of unexpected treatment outcomes, and TDM may help to explain pharmacokinetic particularities after switching from an original to a generic preparation (or vice versa). Finally, the increasing knowledge of the metabolism of psychotropic drugs allows taking account of the pharmacogenetic status (e.g. cytochrome P-450, P-glycoprotein) of the patients not only in adapting their medication, but also for interpreting pharmacokinetic interactions with clinical consequences. In this respect, pharmacokinetic and pharmacogenetic tests have now also to be considered as a tool in pharmacovigilance.
Création de la notice
10/03/2008 11:37
Dernière modification de la notice
03/03/2018 21:04
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