Application in the STRATHE trial of a score system to compare the efficacy and the tolerability of different therapeutic strategies in the management of hypertension

Détails

Ressource 1Télécharger: BIB_BFEB3CDD20A7.P001.pdf (120.32 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_BFEB3CDD20A7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Application in the STRATHE trial of a score system to compare the efficacy and the tolerability of different therapeutic strategies in the management of hypertension
Périodique
Vascular Health and Risk Management
Auteur(s)
Waeber B., Mourad J.J.
ISSN
1176-6344
Statut éditorial
Publié
Date de publication
2008
Volume
4
Numéro
1
Pages
249-252
Langue
anglais
Résumé
A score system integrating the evolution of efficacy and tolerability over time was applied to a subpopulation of the STRATHE trial, a trial performed according to a parallel group design, with a double-blind, random allocation to either a fixed-dose combination strategy (perindopril/indapamide 2 mg/0.625 mg, with the possibility to increase the dose to 3 mg/0.935 mg, and 4 mg/1.250 mg if needed, n = 118), a sequential monotherapy approach (atenolol 50 mg, followed by losartan 50 mg and amlodipine 5 mg if needed, n = 108), or a stepped-care strategy (valsartan 40 mg, followed by valsartan 80 mg and valsartan 80 mg+ hydrochlorothiazide 12.5 mg if needed, n = 103). The aim was to lower blood pressure below 140/90 mmHg within a 9-month period. The treatment could be adjusted after 3 and 6 months. Only patients in whom the study protocol was strictly applied were included in this analysis. At completion of the trial the total score averaged 13.1 +/- 70.5 (mean +/- SD) using the fixed-dose combination strategy, compared with -7.2 +/- 81.0 using the sequential monotherapy approach and -17.5 +/- 76.4 using the stepped-care strategy. In conclusion, the use of a score system allows the comparison of antihypertensive therapeutic strategies, taking into account at the same time efficacy and tolerability. In the STRATHE trial the best results were observed with the fixed-dose combination containing low doses of an angiotensin enzyme converting inhibitor (perindopril) and a diuretic (indapamide).
Mots-clé
Amlodipine, Antihypertensive Agents, Atenolol, Double-Blind Method, Drug Therapy, Combination, France, Humans, Hydrochlorothiazide, Hypertension, Indapamide, Losartan, Perindopril, Randomized Controlled Trials as Topic, Tetrazoles, Treatment Outcome, Valine
Pubmed
Création de la notice
22/01/2009 14:29
Dernière modification de la notice
03/03/2018 21:04
Données d'usage