Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation.

Détails

ID Serval
serval:BIB_BFDED9BC0876
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation.
Périodique
FEMS Yeast Research
Auteur(s)
Sanglard D., Coste A., Ferrari S.
ISSN
1567-1364[electronic]
Statut éditorial
Publié
Date de publication
2009
Volume
9
Numéro
7
Pages
1029-1050
Langue
anglais
Résumé
Fungi are primitive eukaryotes and have adapted to a variety of niches during evolution. Some fungal species may interact with other life forms (plants, insects, mammals), but are considered as pathogens when they cause mild to severe diseases. Chemical control strategies have emerged with the development of several drugs with antifungal activity against pathogenic fungi. Antifungal agents have demonstrated their efficacy by improving patient health in medicine. However, fungi have counteracted antifungal agents in several cases by developing resistance mechanisms. These mechanisms rely on drug resistance genes including multidrug transporters and drug targets. Their regulation is crucial for the development of antifungal drug resistance and therefore transcriptional factors critical for their regulation are being characterized. Recent genome-wide studies have revealed complex regulatory circuits involving these genetic and transcriptional regulators. Here, we review the current understanding of the transcriptional regulation of drug resistance genes from several fungal pathogens including Candida and Aspergillus species.
Mots-clé
Regulation, Antifungal Agents, Resistance , Genome-Wide Expression, Candida-Albicans Biofilms, Amino-Acid Substitutions, Mdr1 Efflux Pump, Reduced Echinocandin Susceptibility, Increased Fluconazole Resistance, Major Facilitator Superfamily, Human-Immunodeficiency-Virus, Sterol 14-Demethylase P450, Transporter-Encoding Gene
Pubmed
Web of science
Création de la notice
03/11/2009 17:02
Dernière modification de la notice
20/08/2019 16:34
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