Pathogenesis of hepatocellular carcinoma.

Détails

ID Serval
serval:BIB_BF8F25B79D96
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Pathogenesis of hepatocellular carcinoma.
Périodique
European journal of gastroenterology & hepatology
Auteur(s)
Moradpour D., Blum H.E.
ISSN
0954-691X
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
17
Numéro
5
Pages
477-83
Langue
anglais
Notes
Publication types: Journal Article ; Review - Publication Status: ppublish
Résumé
Hepatocellular carcinoma (HCC) is one of the most common malignant tumours worldwide. The major aetiologies and risk factors for the development of HCC are well defined and some of the multiple steps involved in hepatocarcinogenesis have been elucidated in recent years. However, no clear picture of how and in what sequence these factors interact at the molecular level has emerged yet. Malignant transformation of hepatocytes may occur as a consequence of various aetiologies, such as chronic viral hepatitis, alcohol, and metabolic disorders, in the context of increased cellular turnover induced by chronic liver injury, regeneration and cirrhosis. Activation of cellular oncogenes, inactivation of tumour suppressor genes, genomic instability, including DNA mismatch repair defects and impaired chromosomal segregation, overexpression of growth and angiogenic factors, and telomerase activation may contribute to the development of HCC. Overall, HCCs are genetically very heterogeneous tumours. New technologies, including gene expression profiling and proteomic analyses, should allow us to further elucidate the molecular events underlying HCC development and identify novel diagnostic markers as well as therapeutic targets.
Mots-clé
Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Genes, Tumor Suppressor, Hepatitis B, Chronic, Hepatitis C, Chronic, Humans, Liver Neoplasms, Oncogenes, Risk Factors
Pubmed
Web of science
Création de la notice
25/01/2008 17:05
Dernière modification de la notice
03/03/2018 21:03
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