Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism.

Détails

ID Serval
serval:BIB_BF8018CE7C1A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism.
Périodique
PloS one
Auteur(s)
Jiménez-Alcázar M., Limacher A., Panda R., Méan M., Bitterling J., Peine S., Renné T., Beer J.H., Aujesky D., Lämmle B., Fuchs T.A.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
13
Numéro
2
Pages
e0191150
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Venous thromboembolism (VTE) is a major cause of morbidity and mortality in elderly patients. Extracellular DNA is a pro-inflammatory and pro-thrombotic mediator in vitro and in animal models. Levels of circulating extracellular DNA (ceDNA) are increased in VTE patients, but the association of ceDNA with VTE extent and clinical outcome is poorly understood.
We analyzed the association of ceDNA with the extent of VTE, categorized as distal and proximal deep vein thrombosis and pulmonary embolism, and with the clinical outcomes VTE recurrence and mortality.
We quantified ceDNA by a fluorescent probe, as well as circulating nucleosomes and neutrophil extracellular traps (NETs) by ELISA in plasma from 611 patients aged ≥ 65 years with acute VTE of a prospective cohort study (SWITCO65+).
Levels of ceDNA and nucleosomes, but not NETs, correlated with VTE extent. Infectious comorbidities independently increased ceDNA levels in VTE. CeDNA strongly correlated with C-reactive protein and leukocytosis, suggesting an association of ceDNA with inflammation in VTE patients. CeDNA furthermore predicted PE-related and all-cause mortality, but not VTE recurrence, during a 3-year follow-up.
Our study suggests that ceDNA levels in VTE patients reflect the degree of inflammation and may serve as a biomarker to stratify VTE patients at risk for mortality.

Mots-clé
Aged, Aged, 80 and over, Biomarkers/blood, C-Reactive Protein/metabolism, Cohort Studies, DNA/blood, Extracellular Fluid/metabolism, Extracellular Traps/metabolism, Female, Humans, Inflammation Mediators/blood, Male, Nucleosomes/metabolism, Prospective Studies, Pulmonary Embolism/blood, Pulmonary Embolism/mortality, Recurrence, Risk Factors, Switzerland/epidemiology, Venous Thromboembolism/blood, Venous Thromboembolism/mortality, Venous Thrombosis/blood, Venous Thrombosis/mortality
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/03/2018 18:48
Dernière modification de la notice
09/05/2019 0:39
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