A prospective immunofluorescence study of 111 cases of pruritic dermatoses of pregnancy: IgM anti-basement membrane zone antibodies as a novel finding

Details

Serval ID
serval:BIB_BF2BA94B2646
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A prospective immunofluorescence study of 111 cases of pruritic dermatoses of pregnancy: IgM anti-basement membrane zone antibodies as a novel finding
Journal
British Journal of Dermatology
Author(s)
Zurn  A., Celebi  C. R., Bernard  P., Didierjean  L., Saurat  J. H.
ISSN
0007-0963 (Print)
Publication state
Published
Issued date
05/1992
Volume
126
Number
5
Pages
474-8
Notes
Journal Article --- Old month value: May
Abstract
Since 1981, all pregnant women presenting to our department with a pruritic dermatosis have been investigated by histological and immunopathological techniques. We recruited 111 patients and performed skin histology in 77, 109 direct immunofluorescence tests (DIF), 74 indirect immunofluorescence tests (IIF) and 15 Western blots (WB). We identified: (i) five typical cases of pemphigoid gestationis (PG) (4.5%), corresponding to an incidence of 1/7000 pregnancies. (ii) Five cases without PG but showing circulating anti-BMZ antibodies of IgM type. With the exception of one case, clinical features were homogeneous--occurrence of erythematous papular and/or urticarial lesions on the trunk, and less often, on the limbs between the 32nd and 38th week of pregnancy. Rapid clearance of lesions within a few days was the rule. Whenever performed, DIF was negative and IIF showed circulating anti-BMZ antibodies of IgM type. Western blot studies were negative in these five cases. (iii) One hundred and one cases with negative immunofluorescence tests, considered to be suffering from polymorphic eruption of pregnancy. Our results show the value of systematic immunopathological investigations in pregnant women presenting with a pruritic dermatosis, and raise the possibility of a new entity, as defined by circulating anti-BMZ antibodies of IgM type.
Keywords
Adult Autoantibodies/*analysis Basement Membrane/*immunology Blotting, Western Female Fluorescent Antibody Technique Humans Immunoglobulin M/*analysis Pregnancy Pregnancy Complications/*immunology Prospective Studies Pruritus/*immunology
Pubmed
Web of science
Create date
28/01/2008 8:44
Last modification date
20/08/2019 15:33
Usage data