Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene.
Publication types: Case Reports ; Journal Article
Muir-Torre syndrome (MTS) is a rare cancer-predisposing syndrome that is autosomal dominantly inherited and characterized by the development of sebaceous skin lesions (adenomas, epitheliomas, basaliomas and carcinomas). These lesions are typically associated with tumors that belong to the spectrum of hereditary nonpolyposis colorectal cancer (HNPCC) (i.e., tumors of the colorectum, endometrium, stomach or ovary). Biliary malignancy in association with MTS has only rarely been reported. We report a case of Muir-Torre syndrome associated with intrahepatic cholangiocarcinoma, a location not previously described, and associated with a novel missense mutation of the MSH2 gene (c.2026T > C), predicted to disrupt the function of the gene.
Adenocarcinoma, Mucinous/genetics, Adenocarcinoma, Mucinous/surgery, Adenoma/genetics, Adenoma/surgery, Adult, Brain Neoplasms/genetics, Brain Neoplasms/secondary, Carcinoma/genetics, Carcinoma/surgery, Cholangiocarcinoma/genetics, Cholangiocarcinoma/secondary, Colorectal Neoplasms, Hereditary Nonpolyposis/genetics, Colorectal Neoplasms, Hereditary Nonpolyposis/surgery, DNA Mutational Analysis, DNA Probes, DNA-Binding Proteins, Endometrial Neoplasms/surgery, Female, Germ-Line Mutation, Humans, Liver Neoplasms/genetics, Liver Neoplasms/surgery, Microsatellite Instability, MutS Homolog 2 Protein/deficiency, Mutation, Missense, Neoplasms, Multiple Primary/genetics, Neoplasms, Multiple Primary/surgery, Neoplastic Syndromes, Hereditary/genetics, Neoplastic Syndromes, Hereditary/surgery, Polyps/surgery, Proline/genetics, Sebaceous Gland Neoplasms/genetics, Sebaceous Gland Neoplasms/surgery, Serine/genetics, Skin Neoplasms/genetics, Skin Neoplasms/secondary, Syndrome
Web of science
Last modification date