Effects of continuous positive airway pressure treatment on coronary vasoreactivity measured by (82)Rb cardiac PET/CT in obstructive sleep apnea patients.

Détails

ID Serval
serval:BIB_BF00B46E23B6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of continuous positive airway pressure treatment on coronary vasoreactivity measured by (82)Rb cardiac PET/CT in obstructive sleep apnea patients.
Périodique
Sleep & breathing = Schlaf & Atmung
Auteur(s)
Dunet V., Rey-Bataillard V., Allenbach G., Beysard N., Lovis A., Prior J.O., Heinzer R.
ISSN
1522-1709 (Electronic)
ISSN-L
1520-9512
Statut éditorial
Publié
Date de publication
05/2016
Peer-reviewed
Oui
Volume
20
Numéro
2
Pages
673-679
Langue
anglais
Notes
Publication types: Controlled Clinical Trial ; Journal Article
Publication Status: ppublish
Résumé
Obstructive sleep apnea syndrome (OSA) increases the risk of cardiovascular disease. We aimed at evaluating the effect of continuous positive airway pressure (CPAP) treatment on coronary endothelium-dependent vasoreactivity in OSA patients by quantifying myocardial blood flow (MBF) response to cold pressure testing (CPT).
In the morning after polysomnography (PSG), all participants underwent a dynamic (82)Rb cardiac positron emitting tomography/computed tomography (PET/CT) scan at rest, during CPT and adenosine stress. PSG and PET/CT were repeated at least 6 weeks after initiating CPAP treatment. OSA patients were compared to controls and according to response to CPAP. Patients' characteristics and PSG parameters were used to determine predictors of CPT-MBF.
Thirty-two untreated OSA patients (age 58 ± 13 years, 27 men) and 9 controls (age 62 ± 5 years, 4 men) were enrolled. At baseline, compared to controls (apnea-hypopnea index (AHI) = 5.3 ± 2.6/h), untreated OSA patients (AHI = 48.6 ± 19.7/h) tend to have a lower CPT-MBF (1.1 ± 0.2 mL/min/g vs. 1.3 ± 0.4 mL/min/g, p = 0.09). After initiating CPAP, CPT-MBF was not different between well-treated patients (AHI <10/h) and controls (1.3 ± 0.3 mL/min/g vs. 1.3 ± 0.4 mL/min/g, p = 0.83), but it was lower for insufficiently treated patients (AHI ≥10/h) (0.9 ± 0.2 mL/min/g vs. 1.3 ± 0.4 mL/min/g, p = 0.0045). CPT-MBF was also higher in well-treated than in insufficiently treated patients (1.3 ± 0.3 mL/min/g vs. 0.9 ± 0.2 mL/min/g, p = 0.001). Mean nocturnal oxygen saturation (β = -0.55, p = 0.02) and BMI (β = -0.58, p = 0.02) were independent predictors of CPT-MBF in OSA patients.
Coronary endothelial vasoreactivity is impaired in insufficiently treated OSA patients compared to well-treated patients and controls, confirming the need for CPAP optimization.

Mots-clé
Adult, Aged, Continuous Positive Airway Pressure, Coronary Circulation/physiology, Coronary Vessels/physiopathology, Endothelium, Vascular/physiopathology, Female, Humans, Male, Middle Aged, Multimodal Imaging, Polysomnography, Positron-Emission Tomography, Rubidium, Sleep Apnea, Obstructive/physiopathology, Sleep Apnea, Obstructive/therapy, Tomography, X-Ray Computed, Vascular Resistance/physiology, Continuous positive airway pressure, Endothelial function, Obstructive sleep apnea, PET
Pubmed
Web of science
Création de la notice
14/01/2016 18:54
Dernière modification de la notice
20/08/2019 16:33
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