Article: article from journal or magazin.
One naive T cell, multiple fates in CD8+ T cell differentiation.
Journal of Experimental Medicine
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish. PDF tpye d'article: Article.
The mechanism by which the immune system produces effector and memory T cells is largely unclear. To allow a large-scale assessment of the development of single naive T cells into different subsets, we have developed a technology that introduces unique genetic tags (barcodes) into naive T cells. By comparing the barcodes present in antigen-specific effector and memory T cell populations in systemic and local infection models, at different anatomical sites, and for TCR-pMHC interactions of different avidities, we demonstrate that under all conditions tested, individual naive T cells yield both effector and memory CD8+ T cell progeny. This indicates that effector and memory fate decisions are not determined by the nature of the priming antigen-presenting cell or the time of T cell priming. Instead, for both low and high avidity T cells, individual naive T cells have multiple fates and can differentiate into effector and memory T cell subsets.
Animals, CD8-Positive T-Lymphocytes/cytology, CD8-Positive T-Lymphocytes/immunology, Cell Differentiation/immunology, Cell Lineage/immunology, Immunologic Memory/immunology, Listeriosis/complications, Listeriosis/immunology, Lymphoid Tissue/cytology, Lymphoid Tissue/immunology, Mice, Mice, Inbred C57BL, Orthomyxoviridae Infections/complications, Orthomyxoviridae Infections/immunology, Receptors, Antigen, T-Cell/immunology, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology
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