Thermic effect of infused amino acids in healthy humans and in subjects with insulin resistance

Details

Serval ID
serval:BIB_BEB27545FCDE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Thermic effect of infused amino acids in healthy humans and in subjects with insulin resistance
Journal
American Journal of Clinical Nutrition
Author(s)
Tappy  L., Jequier  E., Acheson  K.
ISSN
0002-9165 (Print)
Publication state
Published
Issued date
06/1993
Volume
57
Number
6
Pages
912-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
The thermic effect of food has been observed to be decreased in subgroups of obese nondiabetic and obese diabetic subjects. The mechanisms responsible for this decrease have not been fully elucidated. Although protein elicits the largest thermic effect among the various nutrients, most studies have addressed carbohydrate- or fat-induced thermogenesis in insulin resistance. To determine whether the decreased thermic effect of nutrients in insulin-resistant patients could be related to a decrease in protein-induced thermogenesis, glucose [13.9 mumol.kg fat-free mass (FFM)-1.min-1] with or without amino acids (4.2 mg.kg FFM-1.min-1) was infused into a group of six obese nondiabetic subjects (Ob), six obese subjects with non-insulin-dependent diabetes mellitus (NIDDM), and six lean subjects. The thermic effect of infused amino acid (% of infused energy) measured by indirect calorimetry was 21.1 +/- 3.2%, 23.8 +/- 1.8%, and 20.0 +/- 2.9% in lean, Ob, and NIDDM subjects, respectively (NS). It is concluded that the thermic effect of protein is not altered in insulin-resistant patients.
Keywords
Adult Amino Acids/*pharmacology Blood Glucose/analysis Body Temperature/*drug effects Calorimetry, Indirect Catecholamines/urine Diabetes Mellitus/blood/physiopathology/urine Diabetes Mellitus, Type 2/blood/physiopathology Energy Metabolism Humans Infusions, Intravenous Insulin/blood *Insulin Resistance Obesity/physiopathology Reference Values
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 15:33
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