ELM-the Eukaryotic Linear Motif resource-2024 update.

Details

Serval ID
serval:BIB_BE2B431F3782
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
ELM-the Eukaryotic Linear Motif resource-2024 update.
Journal
Nucleic acids research
Author(s)
Kumar M., Michael S., Alvarado-Valverde J., Zeke A., Lazar T., Glavina J., Nagy-Kanta E., Donagh J.M., Kalman Z.E., Pascarelli S., Palopoli N., Dobson L., Suarez C.F., Van Roey K., Krystkowiak I., Griffin J.E., Nagpal A., Bhardwaj R., Diella F., Mészáros B., Dean K., Davey N.E., Pancsa R., Chemes L.B., Gibson T.J.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Publication state
Published
Issued date
05/01/2024
Peer-reviewed
Oui
Volume
52
Number
D1
Pages
D442-D455
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Short Linear Motifs (SLiMs) are the smallest structural and functional components of modular eukaryotic proteins. They are also the most abundant, especially when considering post-translational modifications. As well as being found throughout the cell as part of regulatory processes, SLiMs are extensively mimicked by intracellular pathogens. At the heart of the Eukaryotic Linear Motif (ELM) Resource is a representative (not comprehensive) database. The ELM entries are created by a growing community of skilled annotators and provide an introduction to linear motif functionality for biomedical researchers. The 2024 ELM update includes 346 novel motif instances in areas ranging from innate immunity to both protein and RNA degradation systems. In total, 39 classes of newly annotated motifs have been added, and another 17 existing entries have been updated in the database. The 2024 ELM release now includes 356 motif classes incorporating 4283 individual motif instances manually curated from 4274 scientific publications and including >700 links to experimentally determined 3D structures. In a recent development, the InterPro protein module resource now also includes ELM data. ELM is available at: http://elm.eu.org.
Keywords
Amino Acid Motifs/genetics, Databases, Protein, Protein Processing, Post-Translational, Proteins/genetics, Proteins/metabolism, Eukaryota/genetics, Internet
Pubmed
Web of science
Open Access
Yes
Create date
16/11/2023 15:39
Last modification date
16/01/2024 8:12
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