Article: article from journal or magazin.
In vivo measurement of glycine with short echo-time 1H MRS in human brain at 7 T.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
OBJECT: To determine whether glycine can be measured at 7 T in human brain with (1)H magnetic resonance spectroscopy (MRS). MATERIALS AND METHODS: The glycine singlet is overlapped by the larger signal of myo-inositol. Density matrix simulations were performed to determine the TE at which the myo-inositol signal was reduced the most, following a single spin-echo excitation. (1)H MRS was performed on an actively shielded 7 T scanner, in five healthy volunteers. RESULTS: At the TE of 30 ms, the myo-inositol signal intensity was substantially reduced. Quantification using LCModel yielded a glycine-to-creatine ratio of 0.14 +/- 0.01, with a Cramer-Rao lower bound (CRLB) of 7 +/- 1%. Furthermore, quantification of metabolites other than glycine was possible as well, with a CRLB mostly below 10%. CONCLUSION: It is possible to detect glycine at 7 T in human brain, at the short TE of 30 ms with a single spin-echo excitation scheme.
Algorithms, Brain/metabolism, Glycine/analysis, Humans, Magnetic Resonance Spectroscopy/methods, Neurotransmitter Agents/analysis, Protons/diagnostic use, Reproducibility of Results, Sensitivity and Specificity
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