Trans-scleral diffusion of triamcinolone acetonide.

Détails

ID Serval
serval:BIB_BDE99240C063
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Trans-scleral diffusion of triamcinolone acetonide.
Périodique
Current Eye Research
Auteur(s)
Mora P., Eperon S., Felt-Baeyens O., Gurny R., Sagodira S., Breton P., Guex-Crosier Y.
ISSN
0271-3683
Statut éditorial
Publié
Date de publication
05/2005
Peer-reviewed
Oui
Volume
30
Numéro
5
Pages
355-361
Langue
anglais
Résumé
PURPOSE: To assess ex vivo human scleral permeability to triamcinolone acetonide (TA). METHODS: The experiments were carried out using scleral samples and a Franz-type vertical diffusion cell. A suspension containing TA was prepared and placed in the donor chamber. The concentration of TA in the receptor chamber was measured by high-performance liquid chromatography (HPLC) assay and expressed as a percentage relative to TA concentration dissolved in the donor chamber. Control experiments using a commercial TA suspension were performed. RESULTS: TA (+/-SEM) dissolved in the donor suspension was 10.69 +/- 1.28 microg/ml. The diffusion rate of TA varied from 30% after 1 day to 72% after 4 days, after which equilibrium was reached. The human scleral permeability coefficient (P(s) +/- SEM) was 1.47+/- 0.17 x 10(- 5) cm/s. CONCLUSIONS: TA crossed human sclera. The mean amount of drug retained in the sclera increased with time, 4 days being necessary to equilibrate the unidirectional flux. The TA permeability coefficient was comparable to that of other corticosteroids.
Mots-clé
Chromatography, High Pressure Liquid, Diffusion, Glucocorticoids/pharmacokinetics, Humans, Middle Aged, Permeability, Sclera/metabolism, Triamcinolone Acetonide/pharmacokinetics
Pubmed
Web of science
Création de la notice
17/01/2008 14:27
Dernière modification de la notice
03/03/2018 20:59
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