Comparative genomic and phylogeographic analysis of Mycobacterium leprae.

Détails

ID Serval
serval:BIB_BDCCC23F57D7
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparative genomic and phylogeographic analysis of Mycobacterium leprae.
Périodique
Nature Genetics
Auteur(s)
Monot M., Honoré N., Garnier T., Zidane N., Sherafi D., Paniz-Mondolfi A., Matsuoka M., Taylor G.M., Donoghue H.D., Bouwman A., Mays S., Watson C., Lockwood D., Khamispour A., Dowlati Y., Jianping S., Rea T.H., Vera-Cabrera L., Stefani M.M., Banu S., Macdonald M., Sapkota B.R., Spencer J.S., Thomas J., Harshman K., Singh P., Busso P., Gattiker A., Rougemont J., Brennan P.J., Cole S.T.
ISSN
1546-1718[electronic], 1061-4036[linking]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
41
Numéro
12
Pages
1282-1289
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38x coverage) and NHDP63 (46x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.
Mots-clé
Genes, Bacterial, Genome, Bacterial, Geography, Humans, Leprosy/genetics, Leprosy/microbiology, Mycobacterium leprae/classification, Mycobacterium leprae/genetics, Phylogeny, Polymorphism, Single Nucleotide, Recombination, Genetic
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2010 10:01
Dernière modification de la notice
20/08/2019 16:32
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