Article: article from journal or magazin.
A novel highly informative polyA microsatellite on the telomeric side of the INK4a/ARF locus
Molecular and Cellular Probes
PT - Journal Article PT - Research Support, Non-U.S. Gov't
The INK4a/ARF locus encodes two cell cycle-regulatory proteins, p16(INK4a)and p14(ARF). Inactivation of the p16(INK4a)(MTS1) tumor suppressor gene by mutations, promoter methylation or gene deletions is a common event in the development of many different human tumors. The present report describes a novel polyA mononucleotide repeat situated 7.2 kb on the telomeric side of the INK4a/ARF locus. This highly polymorphic microsatellite marker (heterozygote frequency: 0.78) proved to be efficient for p16 allele loss and microsatellite instability analyses in human colon cancer
Adenocarcinoma/genetics/Alleles/Colon/Pathology/Colonic Neoplasms/Cyclin-Dependent Kinase Inhibitor p16/Heterozygote/Humans/Loss of Heterozygosity/Microsatellite Repeats/Mucous Membrane/Poly A/Polymorphism,Genetic/Proteins/Telomere/ultrastructure/Tumor Suppressor Protein p14ARF
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