Prenatal diagnosis of urinary malformations: results in a series of 93 consecutive cases.

Détails

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Etat: Serval
Version: Final published version
ID Serval
serval:BIB_BDA1786134CB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prenatal diagnosis of urinary malformations: results in a series of 93 consecutive cases.
Périodique
Swiss Medical Weekly
Auteur(s)
Brunisholz Y., Vial Y., Maillard-Brignon C., Meyrat B.J., Frey P., Hohlfeld P.
ISSN
1424-7860
Statut éditorial
Publié
Date de publication
2001
Volume
131
Numéro
7-8
Pages
95-98
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article Publication Status: ppublish
Résumé
OBJECTIVE: To evaluate the pertinence of prenatal diagnosis in cases of congenital uropathy. STUDY DESIGN: Retrospective evaluation over a period of 6.5 years. METHOD: 93 cases were involved in the comparison of prenatal ultrasonographic diagnosis with neonatal findings, autopsy results, and follow-up data. RESULTS: 33 fetuses had renal parenchymal lesions, 44 had excretory system lesions, and 6 had bladder and/or urethral lesions. Seventy-three pregnancies lead to live births. Eighteen terminations of pregnancy were performed on the parents' request for extremely severe malformations. Two intrauterine deaths were observed, and two infants died in the postnatal period. Prenatal diagnosis was obtained at an average of 27 weeks gestation. Diagnostic concordance was excellent in 82% and partial in 12% of cases with renal parenchymal lesions; the false-positive rate was 6%. For excretory system lesions, concordance was excellent in 87% and partial in 7.4% of cases, with a false-positive rate of 5.6%. Finally, concordance was excellent in 100% of cases of bladder and/or urethral lesions. The overall rate of total concordance was 86%. Partial concordance cases consisted of malformations different from those previously diagnosed, but prenatal diagnosis nevertheless lead to further investigations in the neonatal period and to proper management. The false-positive diagnoses (5.4%) never lead to termination of pregnancy. CONCLUSION: Prenatal diagnosis of congenital uropathy is effective. A third-trimester ultrasonographic examination is necessary to ensure proper neonatal management, considering that the majority of cases are diagnosed at this gestational age.
Mots-clé
Adult, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Newborn, Pregnancy, Pregnancy Outcome, Prenatal Diagnosis/methods, Radionuclide Imaging/methods, Retrospective Studies, Sensitivity and Specificity, Urinary Tract/abnormalities, Urogenital Abnormalities/diagnosis, Urologic Diseases/congenital, Urologic Diseases/diagnosis
Pubmed
Web of science
Création de la notice
28/02/2008 11:25
Dernière modification de la notice
03/03/2018 20:59
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