Article: article from journal or magazin.
Corticotropin-releasing hormone promotes blastocyst implantation and early maternal tolerance.
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
The semi-allograft embryo in the blastocyst stage implants itself in the endometrium, yet no immune rejection processes are activated. Embryonic trophoblast and maternal decidua produce corticotropin-releasing hormone (CRH) and express Fas ligand (FasL), a proapoptotic cytokine. We found that antalarmin, a CRH receptor type 1 antagonist, decreased FasL expression and promoted apoptosis of activated T lymphocytes, an effect which was potentiated by CRH and inhibited by antalarmin. Female rats treated with antalarmin showed a marked decrease in implantation sites and live embryos and diminished endometrial FasL expression. Embryos from mothers that lacked T cells or from syngeneic matings were not rejected when the mothers were given antalarmin. These findings suggested that locally produced CRH promotes implantation and maintenance of early pregnancy primarily by killing activated T cells.
Animals, Antigens, CD95/physiology, Apoptosis/drug effects, Blastocyst/immunology, Blastocyst/physiology, Cells, Cultured/drug effects, Cells, Cultured/metabolism, Corticotropin-Releasing Hormone/pharmacology, Corticotropin-Releasing Hormone/physiology, Decidua/immunology, Embryo Implantation/drug effects, Embryo Implantation/physiology, Endometrium/immunology, Endometrium/metabolism, Fas Ligand Protein, Female, Gene Expression Regulation/drug effects, Histocompatibility, Humans, Inflammation, Litter Size/drug effects, Membrane Glycoproteins/biosynthesis, Membrane Glycoproteins/genetics, Pregnancy, Pyrimidines/pharmacology, Pyrimidines/toxicity, Pyrroles/pharmacology, Pyrroles/toxicity, Rats, Rats, Inbred F344, Rats, Nude, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone/antagonists & inhibitors, Receptors, Corticotropin-Releasing Hormone/physiology, T-Lymphocyte Subsets/drug effects, T-Lymphocyte Subsets/immunology, Trophoblasts/immunology
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