Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery

Détails

ID Serval
serval:BIB_BD8D15E5EC75
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of magnesium deficiency on blood pressure and mechanical properties of rat carotid artery
Périodique
Hypertension
Auteur(s)
Laurant  P., Hayoz  D., Brunner  H. R., Berthelot  A.
ISSN
0194-911X (Print)
Statut éditorial
Publié
Date de publication
05/1999
Volume
33
Numéro
5
Pages
1105-10
Notes
Comparative Study
Journal Article --- Old month value: May
Résumé
The purpose of this study was to determine the effect of dietary Mg deficiency (80 mg/kg versus control diet: 960 mg/kg) on blood pressure and mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously with an echo-tracking device. At 19 weeks, systolic, diastolic, and mean blood pressures were higher in Mg-deficient rats. Histological examination showed an increase in cross-sectional area, intima-media thickness, and media-to-lumen ratio in carotid artery of Mg-deficient rats. Mg deficiency did not modify the arterial distensibility-blood pressure curve. At mean blood pressure, arterial distensibility was significantly less in 19-week-old rats than in 5-week-old rats of both control and Mg-deficient groups. A significant interaction between age and Mg-deficient diet on arterial distensibility (P<0.04) indicates an accelerated age-dependent decreased arterial distensibility with Mg deficiency. At 19 weeks, the artery was stiffer in hypertensive Mg-deficient rats, as illustrated by a shift to higher levels of the incremental elastic modulus-stress curve. In conclusion, the increased blood pressure and the vascular morphological alterations observed in Mg-deficient rats may contribute to an accelerated alteration of the wall material, which in turn leads to a stiffening of the carotid artery.
Mots-clé
Age Factors Animals Biomechanics *Blood Pressure Calcium/blood Carotid Artery, Common/pathology/*physiology/ultrasonography Cholesterol/blood Elasticity Hemodynamic Processes Hypertension/blood/etiology/physiopathology Magnesium/blood Magnesium Deficiency/*complications Male Rats Rats, Wistar
Pubmed
Web of science
Création de la notice
17/01/2008 17:38
Dernière modification de la notice
03/03/2018 20:58
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