Influenza vaccination in immunocompromised patients: efficacy and safety.

Détails

ID Serval
serval:BIB_BD4D2CE03BAB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Influenza vaccination in immunocompromised patients: efficacy and safety.
Périodique
Immunotherapy
Auteur(s)
Zbinden D., Manuel O.
ISSN
1750-7448 (Electronic)
ISSN-L
1750-743X
Statut éditorial
Publié
Date de publication
2014
Volume
6
Numéro
2
Pages
131-139
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish. pdf type: Special Report
Modificiation de typage - Bibliomics - AP - Article changé en Review
Résumé
Yearly administration of the influenza vaccine is the main strategy to prevent influenza in immunocompromised patients. Here, we reviewed the recent literature regarding the clinical significance of the influenza virus infection, as well as the immunogenicity and safety of the influenza vaccine in HIV‑infected individuals, solid-organ and stem-cell transplant recipients and patients receiving biological agents. Epidemiological data produced during the 2009 influenza pandemic have confirmed that immunocompromised patients remain at high risk of influenza-associated complications, namely viral and bacterial pneumonia, hospitalization and even death. The immunogenicity of the influenza vaccine is overall reduced in immunocompromised patients, although a significant clinical protection from influenza is expected to be obtained with vaccination. Influenza vaccination is safe in immunocompromised patients. The efficacy of novel strategies to improve the immunogenicity to the vaccine, such as the use of adjuvanted vaccines, boosting doses and intradermal vaccination, needs to be validated in appropriately powered clinical trials.
Pubmed
Web of science
Création de la notice
10/02/2014 12:14
Dernière modification de la notice
04/07/2019 15:23
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