Selectome update: quality control and computational improvements to a database of positive selection.

Détails

Ressource 1Télécharger: BIB_BD16E97A0D18.P001.pdf (3356.25 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_BD16E97A0D18
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Selectome update: quality control and computational improvements to a database of positive selection.
Périodique
Nucleic Acids Research
Auteur(s)
Moretti S., Laurenczy B., Gharib W.H., Castella B., Kuzniar A., Schabauer H., Studer R.A., Valle M., Salamin N., Stockinger H., Robinson-Rechavi M.
ISSN
1362-4962 (Electronic)
ISSN-L
0305-1048
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
42
Numéro
1
Pages
D917-D921
Langue
anglais
Résumé
Selectome (http://selectome.unil.ch/) is a database of positive selection, based on a branch-site likelihood test. This model estimates the number of nonsynonymous substitutions (dN) and synonymous substitutions (dS) to evaluate the variation in selective pressure (dN/dS ratio) over branches and over sites. Since the original release of Selectome, we have benchmarked and implemented a thorough quality control procedure on multiple sequence alignments, aiming to provide minimum false-positive results. We have also improved the computational efficiency of the branch-site test implementation, allowing larger data sets and more frequent updates. Release 6 of Selectome includes all gene trees from Ensembl for Primates and Glires, as well as a large set of vertebrate gene trees. A total of 6810 gene trees have some evidence of positive selection. Finally, the web interface has been improved to be more responsive and to facilitate searches and browsing.
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/10/2013 15:35
Dernière modification de la notice
20/08/2019 16:31
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