Gastric emptying and lingual lipase activity in cystic fibrosis

Détails

ID Serval
serval:BIB_BD12E4D30B8D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gastric emptying and lingual lipase activity in cystic fibrosis
Périodique
Pediatric Research
Auteur(s)
Roulet  M., Weber  A. M., Paradis  Y., Roy  C. C., Chartrand  L., Lasalle  R., Morin  C. L.
ISSN
0031-3998 (Print)
Statut éditorial
Publié
Date de publication
12/1980
Volume
14
Numéro
12
Pages
1360-2
Notes
Journal Article --- Old month value: Dec
Résumé
To identify gastric factors likely to contribute to fat maldigestion and malabsorption in cystic fibrosis (CF), gastric emptying time, secretion rate, and preduodenal lipolytic activity were studied. Gastric emptying of a liquid test meal and gastric acid secretion were determined in five CF teenagers with pancreatic insufficiency and in five healthy controls. During the first hr, the rate of gastric emptying exhibited a linear pattern in both CF patients and controls. Neither the emptying time nor the gastric secretion rate was different. Lingual lipase activity was measured in eight other CF patients with pancreatic insufficiency and in eight controls. Lipase activity was higher (P less than 0.05) in CF patients than in controls with values (mean +/- S.E.) of 34.48 +/- 11.59 and 12.65 +/- 5.60 mumole butyric acid min-1 ml-1, respectively. No correlation with age or body surface was observed. Intragastric lipolysis of a butterfat triglyceride test meal was fast in both groups, but more extensive (P less than 0.05) in CF patients than in controls. The data show that in CF with pancreatic insufficiency, gastric factors contributing to the first step of fat digestion are preserved. In fact, lingual lipase activity was found to be increased, and a more complete intragastric lipolysis was documented.
Mots-clé
Adolescent Butter Cystic Fibrosis/*physiopathology *Gastric Emptying Gastric Juice/secretion Glycerides/metabolism Humans Lipase/*metabolism Lipolysis Pancreas/physiopathology Tongue/*enzymology
Pubmed
Web of science
Création de la notice
24/01/2008 21:33
Dernière modification de la notice
03/03/2018 20:58
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