Calpain3 expression during human cardiogenesis

Détails

ID Serval
serval:BIB_BD02DCC9B1FF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Calpain3 expression during human cardiogenesis
Périodique
Neuromuscular Disorders
Auteur(s)
Fougerousse  F., Anderson  L. V., Delezoide  A. L., Suel  L., Durand  M., Beckmann  J. S.
ISSN
0960-8966 (Print)
Statut éditorial
Publié
Date de publication
06/2000
Volume
10
Numéro
4-5
Pages
251-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Résumé
Transcripts of calpain3, the gene involved in limb girdle muscular dystrophy type 2A, appear in organs other than the skeletal muscle during human development, the first of which being the early embryonic heart. We examined more precisely the spatio-temporal transcription pattern of calpain3 during human cardiogenesis and the appearance of its protein in fetal tissues, and correlated it to titin expression. Different events of the heart's maturation can be recognized: (i) the presence of titin RNA or protein constitute very precocious developmental cardiac markers appearing before the fusion of the two lateral endocardial tubes; (ii) the disappearance of calpain3 RNA from the ventricular compartment later in the embryonic heart. Finally, although calpain3 transcripts are present in the heart, the corresponding protein is not detected elsewhere than in skeletal muscle.
Mots-clé
Age Factors Calpain/*genetics Embryo *Gene Expression Regulation, Developmental Heart/*embryology Humans *Isoenzymes Muscle Fibers/*metabolism Muscle Proteins/genetics Myocardium/*metabolism Peptide Fragments/*genetics Protein Kinases/genetics RNA, Messenger/metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 17:19
Dernière modification de la notice
03/03/2018 20:58
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