Risk factors for young-onset colorectal cancer.

Détails

ID Serval
serval:BIB_BCF8B90E325B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Risk factors for young-onset colorectal cancer.
Périodique
Cancer Causes and Control
Auteur(s)
Rosato Valentina, Bosetti Cristina, Levi Fabio, Polesel Jerry, Zucchetto Antonella, Negri Eva, La Vecchia Carlo
ISSN
1573-7225 (Electronic)
ISSN-L
0957-5243
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
24
Numéro
2
Pages
335-341
Langue
anglais
Notes
Publication types: Journal Article
pdf : ORIGINAL PAPER
Résumé
PURPOSE: We investigated risk factors for colorectal cancer in early-onset cancers, to provide quantitative estimates for major selected risk factors.
METHODS: We analyzed data from three Italian and Swiss case-control studies conducted between 1985 and 2009, including 329 colorectal cancer cases and 1,361 controls aged ≤45 years. We computed odds ratios (ORs) from unconditional logistic regression models, adjusted for major confounding factors.
RESULTS: The OR of young-onset colorectal cancer was 4.50 for family history of colorectal cancer in first-degree relatives, the association being higher in subjects with affected siblings (OR 11.68) than parents (OR 3.75). The ORs of young-onset colorectal cancer were 1.56 for ≥14 drinks/week of alcohol, 1.56 for the highest tertile of processed meat, 0.40 for vegetables, 0.75 for fruit, and 0.78 for fish intake. Among micronutrients, the ORs were 0.52 for β-carotene, 0.68 for vitamin C, 0.38 for vitamin E, and 0.59 for folate. No significant associations emerged for physical activity, overweight, and diabetes.
CONCLUSIONS: This study-the largest on young-onset colorectal cancer-confirms that several recognized risk factors for colorectal cancer are also relevant determinants of young-onset colorectal cancer. Family history of colorectal cancer in particular is a stronger risk factor in young subjects, as compared to middle age and elderly ones.
Pubmed
Web of science
Création de la notice
26/02/2013 20:39
Dernière modification de la notice
03/03/2018 20:57
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