Continuous electrodermal activity as a potential novel neurophysiological biomarker of prognosis after cardiac arrest--A pilot study.

Détails

Ressource 1Demande d'une copieEtat: Supprimée
Version: de l'auteur
ID Serval
serval:BIB_BCEBDCB8ABD2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Continuous electrodermal activity as a potential novel neurophysiological biomarker of prognosis after cardiac arrest--A pilot study.
Périodique
Resuscitation
Auteur(s)
Alvarez V., Reinsberger C., Scirica B., O'Brien M.H., Avery K.R., Henderson G., Lee J.W.
ISSN
1873-1570 (Electronic)
ISSN-L
0300-9572
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
93
Pages
128-135
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
AIMS: Neurological outcome prognosis remains challenging in patients undergoing therapeutic hypothermia (TH) after cardiac resuscitation. Technological advances allow for a novel wrist-worn device to continuously record electrodermal activity (EDA), a measure of pure sympathetic activity.
METHODS: A prospective cohort study was performed to determine the yield of continuous EDA in patients treated with TH for coma after cardiac arrest during hypothermia and normothermia. Association between EDA parameters (event-related and nonspecific electrodermal responses (ER-EDR, NS-EDR)) and outcome measures (cerebral performance category [CPC]) (Full Outline in UnResponsivenss (FOUR) score) were assessed.
RESULTS: Eighteen patients were enrolled. Total number of EDR (66.4 vs 12.0/24h, p = 0.02), ER-EDR (39.5 vs 11.2/24h, p = 0.009), median amplitude change of all EDR (0.08 vs 0.03 μSI, p = 0.03) and ER-EDR (0.14 vs 0.05 μSI, p = 0.025) were higher in patients with favorable (CPC 1-2) versus poor outcome (CPC 3-5) during hypothermia. Greater differences in EDA parameters were observed during hypothermia than normothermia. The FOUR score was correlated to the number of all EDR and median amplitudes.
CONCLUSIONS: Continuous EDA potentially opens a new avenue for autonomic function monitoring in neurocritically ill patients. It is feasible in the ICU setting, even during hypothermic states. As a measure of a complete neurophysiological circuit, it may be a novel neurophysiologic biomarker of outcome after cardiac resuscitation.
Mots-clé
Adult, Aged, Autonomic Nervous System Diseases/diagnosis, Autonomic Nervous System Diseases/etiology, Cardiopulmonary Resuscitation/adverse effects, Cardiopulmonary Resuscitation/methods, Coma/etiology, Coma/therapy, Electrodiagnosis/instrumentation, Electrodiagnosis/methods, Female, Galvanic Skin Response/physiology, Heart Arrest/complications, Heart Arrest/therapy, Humans, Hypothermia, Induced/adverse effects, Hypothermia, Induced/methods, Male, Middle Aged, Neurologic Examination, Outcome and Process Assessment (Health Care), Pilot Projects, Prognosis, United States
Pubmed
Création de la notice
10/05/2016 21:28
Dernière modification de la notice
03/03/2018 20:57
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