Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.

Détails

ID Serval
serval:BIB_BCCB3F25360E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.
Périodique
Journal of Experimental Medicine
Auteur(s)
Nestle F.O., Conrad C., Tun-Kyi A., Homey B., Gombert M., Boyman O., Burg G., Liu Y.J., Gilliet M.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
2005
Volume
202
Numéro
1
Pages
135-143
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Psoriasis is one of the most common T cell-mediated autoimmune diseases in humans. Although a role for the innate immune system in driving the autoimmune T cell cascade has been proposed, its nature remains elusive. We show that plasmacytoid predendritic cells (PDCs), the natural interferon (IFN)-alpha-producing cells, infiltrate the skin of psoriatic patients and become activated to produce IFN-alpha early during disease formation. In a xenograft model of human psoriasis, we demonstrate that blocking IFN-alpha signaling or inhibiting the ability of PDCs to produce IFN-alpha prevented the T cell-dependent development of psoriasis. Furthermore, IFN-alpha reconstitution experiments demonstrated that PDC-derived IFN-alpha is essential to drive the development of psoriasis in vivo. These findings uncover a novel innate immune pathway for triggering a common human autoimmune disease and suggest that PDCs and PDC-derived IFN-alpha represent potential early targets for the treatment of psoriasis.
Mots-clé
Animals, Dendritic Cells/immunology, Dendritic Cells/pathology, Humans, Immunity, Innate, Interferon-alpha/biosynthesis, Interferon-beta/metabolism, Kinetics, Mice, Mice, Knockout, Plasma Cells/immunology, Plasma Cells/pathology, Psoriasis/etiology, Psoriasis/immunology, Signal Transduction, Skin Transplantation/immunology, Skin Transplantation/pathology, Stem Cells/immunology, Stem Cells/pathology, T-Lymphocytes/immunology, Transplantation, Heterologous
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/03/2012 11:34
Dernière modification de la notice
09/05/2019 0:31
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