GAP-independent functions of DLC1 in metastasis.

Détails

Ressource 1Télécharger: 5_24338004_Postprint.pdf (1272.17 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_BCC4B8BC9438
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
GAP-independent functions of DLC1 in metastasis.
Périodique
Cancer Metastasis Reviews
Auteur(s)
Barras D., Widmann C.
ISSN
1573-7233 (Electronic)
ISSN-L
0167-7659
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
33
Numéro
1
Pages
87-100
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Metastases are responsible for most cancer-related deaths. One of the hallmarks of metastatic cells is increased motility and migration through extracellular matrixes. These processes rely on specific small GTPases, in particular those of the Rho family. Deleted in liver cancer-1 (DLC1) is a tumor suppressor that bears a RhoGAP activity. This protein is lost in most cancers, allowing malignant cells to proliferate and disseminate in a Rho-dependent manner. However, DLC1 is also a scaffold protein involved in alternative pathways leading to tumor and metastasis suppressor activities. Recently, substantial information has been gathered on these mechanisms and this review is aiming at describing the potential and known alternative GAP-independent mechanisms allowing DLC1 to impair migration, invasion, and metastasis formation.
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/05/2014 18:20
Dernière modification de la notice
09/05/2019 0:30
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