Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.

Détails

ID Serval
serval:BIB_BCBAFC9AB2BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression.
Périodique
Nature genetics
Auteur(s)
Wray N.R., Ripke S., Mattheisen M., Trzaskowski M., Byrne E.M., Abdellaoui A., Adams M.J., Agerbo E., Air T.M., Andlauer TMF, Bacanu S.A., Bækvad-Hansen M., Beekman AFT, Bigdeli T.B., Binder E.B., Blackwood DRH, Bryois J., Buttenschøn H.N., Bybjerg-Grauholm J., Cai N., Castelao E., Christensen J.H., Clarke T.K., Coleman JIR, Colodro-Conde L., Couvy-Duchesne B., Craddock N., Crawford G.E., Crowley C.A., Dashti H.S., Davies G., Deary I.J., Degenhardt F., Derks E.M., Direk N., Dolan C.V., Dunn E.C., Eley T.C., Eriksson N., Escott-Price V., Kiadeh FHF, Finucane H.K., Forstner A.J., Frank J., Gaspar H.A., Gill M., Giusti-Rodríguez P., Goes F.S., Gordon S.D., Grove J., Hall L.S., Hannon E., Hansen C.S., Hansen T.F., Herms S., Hickie I.B., Hoffmann P., Homuth G., Horn C., Hottenga J.J., Hougaard D.M., Hu M., Hyde C.L., Ising M., Jansen R., Jin F., Jorgenson E., Knowles J.A., Kohane I.S., Kraft J., Kretzschmar W.W., Krogh J., Kutalik Z., Lane J.M., Li Y., Li Y., Lind P.A., Liu X., Lu L., MacIntyre D.J., MacKinnon D.F., Maier R.M., Maier W., Marchini J., Mbarek H., McGrath P., McGuffin P., Medland S.E., Mehta D., Middeldorp C.M., Mihailov E., Milaneschi Y., Milani L., Mill J., Mondimore F.M., Montgomery G.W., Mostafavi S., Mullins N., Nauck M., Ng B., Nivard M.G., Nyholt D.R., O'Reilly P.F., Oskarsson H., Owen M.J., Painter J.N., Pedersen C.B., Pedersen M.G., Peterson R.E., Pettersson E., Peyrot W.J., Pistis G., Posthuma D., Purcell S.M., Quiroz J.A., Qvist P., Rice J.P., Riley B.P., Rivera M., Saeed Mirza S., Saxena R., Schoevers R., Schulte E.C., Shen L., Shi J., Shyn S.I., Sigurdsson E., Sinnamon GBC, Smit J.H., Smith D.J., Stefansson H., Steinberg S., Stockmeier C.A., Streit F., Strohmaier J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Tian C., Traylor M., Treutlein J., Trubetskoy V., Uitterlinden A.G., Umbricht D., Van der Auwera S., van Hemert A.M., Viktorin A., Visscher P.M., Wang Y., Webb B.T., Weinsheimer S.M., Wellmann J., Willemsen G., Witt S.H., Wu Y., Xi H.S., Yang J., Zhang F., Arolt V., Baune B.T., Berger K., Boomsma D.I., Cichon S., Dannlowski U., de Geus ECJ, DePaulo J.R., Domenici E., Domschke K., Esko T., Grabe H.J., Hamilton S.P., Hayward C., Heath A.C., Hinds D.A., Kendler K.S., Kloiber S., Lewis G., Li Q.S., Lucae S., Madden PFA, Magnusson P.K., Martin N.G., McIntosh A.M., Metspalu A., Mors O., Mortensen P.B., Müller-Myhsok B., Nordentoft M., Nöthen M.M., O'Donovan M.C., Paciga S.A., Pedersen N.L., Penninx BWJH, Perlis R.H., Porteous D.J., Potash J.B., Preisig M., Rietschel M., Schaefer C., Schulze T.G., Smoller J.W., Stefansson K., Tiemeier H., Uher R., Völzke H., Weissman M.M., Werge T., Winslow A.R., Lewis C.M., Levinson D.F., Breen G., Børglum A.D., Sullivan P.F.
Collaborateur(s)
eQTLGen, 23andMe, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Statut éditorial
Publié
Date de publication
05/2018
Peer-reviewed
Oui
Volume
50
Numéro
5
Pages
668-681
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal, whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine the basis of major depression and imply that a continuous measure of risk underlies the clinical phenotype.
Mots-clé
Case-Control Studies, Depressive Disorder, Major/genetics, Female, Genetic Predisposition to Disease, Genome-Wide Association Study/methods, Humans, Male, Multifactorial Inheritance, Phenotype, Polymorphism, Single Nucleotide, Risk Factors, Schizophrenia/genetics
Pubmed
Web of science
Création de la notice
01/05/2018 14:06
Dernière modification de la notice
20/08/2019 16:30
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