EEG reactivity to pain in comatose patients: Importance of the stimulus type.

Détails

Ressource 1Télécharger: BIB_BCADDCE68D18.P001.pdf (3438.46 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_BCADDCE68D18
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
EEG reactivity to pain in comatose patients: Importance of the stimulus type.
Périodique
Resuscitation
Auteur(s)
Tsetsou S., Novy J., Oddo M., Rossetti A.O.
ISSN
1873-1570 (Electronic)
ISSN-L
0300-9572
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
97
Pages
34-37
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
INTRODUCTION: Electroencephalogram (EEG) background reactivity is a potentially interesting outcome predictor in comatose patients, especially after cardiac arrest, but recent studies report only fair interrater reliability. Furthermore, there are no definite guidelines for its testing. We therefore investigated the EEG effect of standardized noxious stimuli in comatose patients not reactive to auditory stimuli.
METHODS: In this prospective study we applied a protocol using three different painful stimuli (bilateral nipple pinching, pinprick at the nose base, finger-nail compression on each side), grouped in three distinct clusters with an alternated sequence, during EEG recordings in comatose patients. We only analyzed recordings showing any reactivity to pain. Fisher and χ2 tests were used as needed to assess contingency tables.
RESULTS: Of 42 studies, 12 did not show any background reactivity, 2 presented SIRPIDs, and 2 had massive artefacts; we thus analyzed 26 EEGs recorded in 17 patients (4 women, 24%). Nipple pinching more frequently induced a change in EEG background activity (p<0.001), with a sensitivity of 97.4% for reactivity. Neither the order of the stimuli in the cluster (p=0.723), nor the cluster order (p=0.901) influenced the results.
CONCLUSION: In this pilot study, bilateral, synchronous nipple pinching seems to be the most efficient method to test nociceptive EEG reactivity in comatose patients. This approach may enhance interrater reliability, but deserves confirmation in larger cohorts.
Mots-clé
Coma/physiopathology, Electroencephalography, Female, Humans, Male, Pain/physiopathology, Physical Stimulation/methods, Pilot Projects, Prospective Studies
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/10/2015 17:35
Dernière modification de la notice
09/05/2019 0:30
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