Function and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural Circuits.

Détails

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Etat: Serval
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_BC5131A9302F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Function and Dysfunction of Microglia during Brain Development: Consequences for Synapses and Neural Circuits.
Périodique
Frontiers in synaptic neuroscience
Auteur(s)
Paolicelli R.C., Ferretti M.T.
ISSN
1663-3563 (Print)
ISSN-L
1663-3563
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
9
Pages
9
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
Many diverse factors, ranging from stress to infections, can perturb brain homeostasis and alter the physiological activity of microglia, the immune cells of the central nervous system. Microglia play critical roles in the process of synaptic maturation and brain wiring during development. Any perturbation affecting microglial physiological function during critical developmental periods could result in defective maturation of synaptic circuits. In this review, we critically appraise the recent literature on the alterations of microglial activity induced by environmental and genetic factors occurring at pre- and early post-natal stages. Furthermore, we discuss the long-lasting consequences of early-life microglial perturbation on synaptic function and on vulnerability to neurodevelopmental and psychiatric disorders.
Mots-clé
brain development, infections, microglia, neurodevelopmental disorders, stress, synapses, synaptic function, synaptic pruning
Pubmed
Open Access
Oui
Création de la notice
18/12/2018 11:33
Dernière modification de la notice
18/06/2019 6:26
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