C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy Using [99mTc]Tc-Pentixatec in Primary Aldosteronism: A Proof-of-Concept Study.

Details

Serval ID
serval:BIB_BC4D38861002
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy Using [99mTc]Tc-Pentixatec in Primary Aldosteronism: A Proof-of-Concept Study.
Journal
Journal of nuclear medicine
Author(s)
Enke J.S., Ritzel K., Asbach E., Reitsam N.G., Märkl B., Knösel T., Brüdgam D., Kircher M., Pfob C.H., Bundschuh R.A., Rinscheid A., Nittbaur B., Wienand G., Schottelius M., Reincke M., Lapa C., Dierks A.
ISSN
1535-5667 (Electronic)
ISSN-L
0161-5505
Publication state
Published
Issued date
01/10/2024
Peer-reviewed
Oui
Volume
65
Number
10
Pages
1640-1644
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
C-X-C motif chemokine receptor 4 (CXCR4)-directed imaging has gained clinical interest in aiding clinical diagnostics in primary aldosteronism (PA). We retrospectively evaluated the feasibility of CXCR4-directed scintigraphy using the novel CXCR-4 ligand [ <sup>99m</sup> Tc]Tc-pentixatec in patients with PA. Methods: Six patients (mean age ± SD, 49 ± 15 y) underwent CXCR4-directed scintigraphy (including planar imaging and SPECT/CT) 30, 120, and 240 min after injection of 435 ± 50 MBq of [ <sup>99m</sup> Tc]Tc-pentixatec. Adrenal CXCR4 expression was analyzed by calculating lesion-to-contralateral ratios (LCRs). Imaging results were correlated to clinical information. Histopathology and clinical follow-up served as the standard of reference. Results: Three subjects showed lateralization of adrenal tracer accumulation, with a mean maximum lesion-to-contralateral ratio of 1.65 (range, 1.52-1.70), which correlated with morphologic findings on CT. One individual underwent adrenalectomy and presented with complete biochemical and clinical remission at follow-up. Histopathologic workup confirmed unilateral aldosterone-producing adenoma. Conclusion: [ <sup>99m</sup> Tc]Tc-pentixatec scintigraphy with SPECT in patients with PA is feasible and might offer a valuable alternative to CXCR4-directed imaging with [ <sup>68</sup> Ga]Ga-pentixafor PET.
Keywords
Humans, Middle Aged, Hyperaldosteronism/diagnostic imaging, Male, Female, Receptors, CXCR4/metabolism, Organotechnetium Compounds, Adult, Retrospective Studies, Proof of Concept Study, Aged, Single Photon Emission Computed Tomography Computed Tomography, Radiopharmaceuticals, Adrenal Glands/diagnostic imaging, CXCR4-directed imaging, primary aldosteronism, scintigraphy
Pubmed
Create date
13/09/2024 13:23
Last modification date
05/10/2024 6:02
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