C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy Using [99mTc]Tc-Pentixatec in Primary Aldosteronism: A Proof-of-Concept Study.
Details
Serval ID
serval:BIB_BC4D38861002
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
C-X-C Motif Chemokine Receptor 4–Directed Scintigraphy Using [99mTc]Tc-Pentixatec in Primary Aldosteronism: A Proof-of-Concept Study.
Journal
Journal of nuclear medicine
ISSN
1535-5667 (Electronic)
ISSN-L
0161-5505
Publication state
Published
Issued date
01/10/2024
Peer-reviewed
Oui
Volume
65
Number
10
Pages
1640-1644
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
C-X-C motif chemokine receptor 4 (CXCR4)-directed imaging has gained clinical interest in aiding clinical diagnostics in primary aldosteronism (PA). We retrospectively evaluated the feasibility of CXCR4-directed scintigraphy using the novel CXCR-4 ligand [ <sup>99m</sup> Tc]Tc-pentixatec in patients with PA. Methods: Six patients (mean age ± SD, 49 ± 15 y) underwent CXCR4-directed scintigraphy (including planar imaging and SPECT/CT) 30, 120, and 240 min after injection of 435 ± 50 MBq of [ <sup>99m</sup> Tc]Tc-pentixatec. Adrenal CXCR4 expression was analyzed by calculating lesion-to-contralateral ratios (LCRs). Imaging results were correlated to clinical information. Histopathology and clinical follow-up served as the standard of reference. Results: Three subjects showed lateralization of adrenal tracer accumulation, with a mean maximum lesion-to-contralateral ratio of 1.65 (range, 1.52-1.70), which correlated with morphologic findings on CT. One individual underwent adrenalectomy and presented with complete biochemical and clinical remission at follow-up. Histopathologic workup confirmed unilateral aldosterone-producing adenoma. Conclusion: [ <sup>99m</sup> Tc]Tc-pentixatec scintigraphy with SPECT in patients with PA is feasible and might offer a valuable alternative to CXCR4-directed imaging with [ <sup>68</sup> Ga]Ga-pentixafor PET.
Keywords
Humans, Middle Aged, Hyperaldosteronism/diagnostic imaging, Male, Female, Receptors, CXCR4/metabolism, Organotechnetium Compounds, Adult, Retrospective Studies, Proof of Concept Study, Aged, Single Photon Emission Computed Tomography Computed Tomography, Radiopharmaceuticals, Adrenal Glands/diagnostic imaging, CXCR4-directed imaging, primary aldosteronism, scintigraphy
Pubmed
Create date
13/09/2024 13:23
Last modification date
05/10/2024 6:02