Antibiotic susceptibility of Neochlamydia hartmanellae and Parachlamydia acanthamoebae in amoebae.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_BBCB5EDD36F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Antibiotic susceptibility of Neochlamydia hartmanellae and Parachlamydia acanthamoebae in amoebae.
Périodique
Microbes and Infection
Auteur(s)
Vouga M., Diabi H., Boulos A., Baud D., Raoult D., Greub G.
ISSN
1769-714X (Electronic)
ISSN-L
1286-4579
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
17
Numéro
11-12
Pages
761-765
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Parachlamydia acanthamoebae and Neochlamydia hartmanellae are Chlamydia-related bacteria naturally infecting free-living amoebae. These strict intracellular bacteria might represent emerging pathogens. Recent studies report an association with lower respiratory tract infections, especially with pneumonia where they have been identified as a potential causative agent in 1-2% of cases. In this study, we defined the antibiotic susceptibility of N. hartmanellae, two strains of P. acanthamoebae and two yet unclassified Parachlamydiaceae strains using a quantitative approach. We confirmed the results obtained earlier for P. acanthamoebae strain Bn9 in an observational study. Macrolides (MICs < 0.06-0.5 μg/ml), rifampicin (MICs 0.25-2) and doxycycline (2-4 μg/ml) were active against P. acanthamoebae strains and Neochlamydia. All strains were resistant to amoxicillin, ceftriaxone and imipenem (MIC ≥32 μg/ml). Similarly to other Chlamydia-related bacteria, all investigated Parachlamydiaceae were resistant to quinolones (MICs ≥ 16 μg/ml). Therefore, we recommend a treatment with macrolides for Parachlamydia-associated pneumonia.
Pubmed
Web of science
Open Access
Oui
Création de la notice
03/01/2016 16:38
Dernière modification de la notice
20/08/2019 15:29
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