PET and plasma pharmacokinetic studies after bolus intravenous administration of [11C]melatonin in humans.
Details
Serval ID
serval:BIB_BBC7C73822E6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
PET and plasma pharmacokinetic studies after bolus intravenous administration of [11C]melatonin in humans.
Journal
International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology
ISSN
0969-8051
ISSN-L
0883-2897
Publication state
Published
Issued date
1991
Volume
18
Number
3
Pages
357-362
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
A human PET study was performed with carbon-11 labelled melatonin in a healthy volunteer. Plasma pharmacokinetics of melatonin and 6-sulfatoxymelatonin were simultaneously determined using radioimmunoassay. Analysis of tracer kinetics showed maximum activity in the brain 8.5 min following injection, which was different from the curve observed for the plasma radioactivity (maximum at 3.5 min). The results confirmed that melatonin readily crosses the blood-brain barrier and that 6-sulfatoxymelatonin is the main plasma metabolite. The distribution of tracer as a function of time in this study failed to reveal any specific binding.
Keywords
Adult, Brain/radionuclide imaging, Brain Chemistry, Carbon Isotopes, Humans, Injections, Intravenous, Male, Melatonin/administration & dosage, Melatonin/adverse effects, Radioimmunoassay, Tomography, Emission-Computed
Pubmed
Web of science
Create date
06/10/2011 20:14
Last modification date
20/08/2019 16:29
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