Early-onset Crohn's disease is a risk factor for smaller final height

Details

Serval ID
serval:BIB_BAC144070B95
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Early-onset Crohn's disease is a risk factor for smaller final height
Journal
European Journal of Gastroenterology and Hepatology
Author(s)
Herzog D., Fournier N., Buehr P., Koller R., Rueger V., Heyland K., Nydegger A., Spalinger J., Schibli S., Braegger C.
Working group(s)
On behalf of the Swiss IBD Cohort Study Group
ISSN
1473-5687 (Electronic)
ISSN-L
0954-691X
Publication state
Published
Issued date
11/2014
Peer-reviewed
Oui
Volume
26
Number
11
Pages
1234-1239
Language
english
Notes
IUMSP2014/11
Abstract
OBJECTIVES: Growth retardation is a frequent complication of paediatric inflammatory bowel disease (IBD). Only a few studies report the final height of these patients, with controversial results. We compared adult height of patients with paediatric IBD with that of patients with adult-onset disease.
METHODS: Height data of 675 women 19-44 years of age and 454 men 23-44 years of age obtained at inclusion in the Swiss IBD cohort study registry were grouped according to the age at diagnosis: (a) prepubertal (men≤13, women≤11 years), (b) pubertal (men 13-22, women 11-18 years) and (c) adult (men>22, women>18 years of age), and compared with each other and with healthy controls.
RESULTS: Male patients with prepubertal onset of Crohn's disease (CD) had significantly lower final height (mean 172±6 cm, range 161-182) compared with men with pubertal (179±6 cm, 161-192) or adult (178±7 cm, 162-200) age at onset and the general population (178±7 cm, 142-204). Height z-scores standardized against heights of the normal population were significantly lower in all patients with a prepubertal diagnosis of CD (-0.8±0.9) compared with the other patient groups (-0.1±0.8, P<0.001). Prepubertal onset of CD emerged as a risk factor for reduced final height in patients with prepubertal CD. No difference for final height was found between patients with ulcerative or unclassified IBD diagnosed at prepubertal, pubertal or adult age.
CONCLUSION: Prepubertal onset of CD is a risk for lower final height, independent of the initial disease location and the necessity for surgical interventions.
Pubmed
Web of science
Create date
29/09/2014 7:03
Last modification date
20/08/2019 15:28
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