Cutaneous leishmaniasis: progress towards a vaccine.

Détails

ID Serval
serval:BIB_BA5960FD51AB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Cutaneous leishmaniasis: progress towards a vaccine.
Périodique
Expert Review of Vaccines
Auteur(s)
Launois P., Tacchini-Cottier F., Kieny M.P.
ISSN
1744-8395 (Electronic)
ISSN-L
1476-0584
Statut éditorial
Publié
Date de publication
2008
Volume
7
Numéro
8
Pages
1277-1287
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Leishmaniases are vector-borne diseases due to the protozoan parasite Leishmania . Since no prevention method is available and as current therapy is costly, often poorly tolerated and not always efficacious, the development of alternative therapies, including vaccines, constitutes the priority in the fight of Leishmania infection. This review focuses on recent advances in the development of vaccines against leishmaniasis, with emphasis on the cutaneous form. Indeed, the fact that recovery from leishmaniasis is associated with immunity against new infection provides a rational basis for the development of vaccination strategy against infection with Leishmania . Evidence from animal studies demonstrate that protection can be achieved following infection with live-attenuated Leishmania as well as through immunization with purified proteins or DNA vaccines. In addition, recent results have shown that immunization against the saliva of the insect vector could have synergistic effects with conventional vaccination. Finally, vaccination using dendritic cells was recently demonstrated as a possible tool for Leishmania vaccination.
Mots-clé
Animals, Dendritic Cells/immunology, Humans, Insects/immunology, Leishmania/immunology, Leishmaniasis Vaccines/immunology, Leishmaniasis, Cutaneous/prevention & control, Saliva/immunology, Vaccines, Attenuated/immunology, Vaccines, DNA/immunology, Vaccines, Subunit/immunology
Pubmed
Web of science
Création de la notice
29/01/2009 23:14
Dernière modification de la notice
20/08/2019 16:28
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