Accelerated T<sub>2</sub> mapping combining parallel MRI and model-based reconstruction: GRAPPATINI.

Détails

ID Serval
serval:BIB_BA03EBD668F3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Accelerated T<sub>2</sub> mapping combining parallel MRI and model-based reconstruction: GRAPPATINI.
Périodique
Journal of magnetic resonance imaging
Auteur(s)
Hilbert T., Sumpf T.J., Weiland E., Frahm J., Thiran J.P., Meuli R., Kober T., Krueger G.
ISSN
1522-2586 (Electronic)
ISSN-L
1053-1807
Statut éditorial
Publié
Date de publication
15/02/2018
Peer-reviewed
Oui
Volume
48
Numéro
2
Pages
359-368
Langue
anglais
Notes
Publication types: Journal Article

Résumé
Quantitative T <sub>2</sub> measurements are sensitive to intra- and extracellular water accumulation and myelin loss. Therefore, quantitative T <sub>2</sub> promises to be a good biomarker of disease. However, T <sub>2</sub> measurements require long acquisition times.
To accelerate T <sub>2</sub> quantification and subsequent generation of synthetic T <sub>2</sub> -weighted (T <sub>2</sub> -w) image contrast for clinical research and routine. To that end, a recently developed model-based approach for rapid T <sub>2</sub> and M <sub>0</sub> quantification (MARTINI) based on undersampling k-space, was extended by parallel imaging (GRAPPA) to enable high-resolution T <sub>2</sub> mapping with access to T <sub>2</sub> -w images in less than 2 minutes acquisition time for the entire brain.
Prospective cross-sectional study.
Fourteen healthy subjects and a multipurpose phantom.
Carr-Purcell-Meiboom-Gill sequence at a 3T scanner.
The accuracy and reproducibility of the accelerated T <sub>2</sub> quantification was assessed. Validations comprised MRI studies on a phantom as well as the brain, knee, prostate, and liver from healthy volunteers. Synthetic T <sub>2</sub> -w images were generated from computed T <sub>2</sub> and M <sub>0</sub> maps and compared to conventional fast spin-echo (SE) images.
Root mean square distance (RMSD) to the reference method and region of interest analysis.
The combination of MARTINI and GRAPPA (GRAPPATINI) lead to a 10-fold accelerated T <sub>2</sub> mapping protocol with 1:44 minutes acquisition time and full brain coverage. The RMSD of GRAPPATINI increases less (4.3%) than a 10-fold MARTINI reconstruction (37.6%) in comparison to the reference. Reproducibility tests showed low standard deviation (SD) of T <sub>2</sub> values in regions of interest between scan and rescan (<0.4 msec) and across subjects (<4 msec).
GRAPPATINI provides highly reproducible and fast whole-brain T <sub>2</sub> maps and arbitrary synthetic T <sub>2</sub> -w images in clinically compatible acquisition times of less than 2 minutes. These abilities are expected to support more widespread clinical applications of quantitative T <sub>2</sub> mapping.
2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018.
Mots-clé
T2 mapping, model-based reconstruction, parametric mapping, quantitative MRI
Pubmed
Web of science
Création de la notice
01/03/2018 20:57
Dernière modification de la notice
20/08/2019 15:28
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