Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.
Details
Serval ID
serval:BIB_B9A6ED2EDBC0
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Listeria brain abscess, Pneumocystis pneumonia and Kaposi's sarcoma after temozolomide.
Journal
Nature Clinical Practice. Oncology
ISSN
1743-4254
Publication state
Published
Issued date
2006
Peer-reviewed
Oui
Volume
3
Number
6
Pages
339-343; quiz following 343
Language
english
Notes
Publication types: Case Reports ; Journal Article
Abstract
BACKGROUND: A 55-year-old man with glioblastoma multiforme was treated with continuous, dose-dense temozolomide. This therapy was curtailed after three cycles because of nausea, asthenia, and neuropsychological deterioration. During a subsequent course of radiotherapy, the patient developed fever, headaches, and cutaneous lesions. INVESTIGATIONS: Physical examination, cerebral MRI, brain biopsy, skin biopsy, immunohistochemistry, bronchoscopy with bronchoalveolar lavage, and laboratory tests. DIAGNOSIS: Severe temozolomide-induced immunosuppression, exacerbated by corticosteroids, with profound T-cell lymphocytopenia and simultaneous opportunistic infections with Pneumocystis jiroveci pneumonia, brain abscess with Listeria monocytogenes, and cutaneous Kaposi's sarcoma. MANAGEMENT: Discontinuation of temozolomide, discontinuation of radiotherapy, antibiotic treatment with amoxicillin and gentamicin, and administration of atovaquone and pentamidine.
Keywords
Antineoplastic Agents, Alkylating, Brain Abscess, Brain Neoplasms, Dacarbazine, Glioblastoma, Humans, Listeria Infections, Male, Middle Aged, Neoadjuvant Therapy, Pneumocystis jirovecii, Pneumonia, Pneumocystis, Sarcoma, Kaposi
Pubmed
Web of science
Create date
25/04/2008 8:22
Last modification date
20/08/2019 15:27