Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Cis interactions of immunoreceptors with MHC and non-MHC ligands
Nature Reviews. Immunology
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
The conventional wisdom is that cell-surface receptors interact with ligands expressed on other cells to mediate cell-to-cell communication (trans interactions). Unexpectedly, it has recently been found that two classes of receptors specific for MHC class I molecules not only interact with MHC class I molecules expressed on opposing cells, but also with those on the same cell. These cis interactions are a feature of immunoreceptors that inhibit, rather than activate, cellular functions. Here, we review situations in which cis interactions have been observed, the characteristics of receptors that bind in trans and cis, and the biological roles of cis recognition.
Animals, B-Lymphocytes/immunology, Cytotoxicity, Immunologic, HLA Antigens/immunology, Humans, Killer Cells, Natural/immunology, Major Histocompatibility Complex/immunology, Mast Cells/immunology, Receptors, Immunologic, T-Lymphocytes/immunology
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