An unusual cause of shoulder pain: undisplaced Salter-Harris type I fracture of the coracoid process.

Détails

Ressource 1Télécharger: BIB_B99C856BBCC4.P001.pdf (543.80 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_B99C856BBCC4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
An unusual cause of shoulder pain: undisplaced Salter-Harris type I fracture of the coracoid process.
Périodique
American Journal of Orthopedics (belle Mead, N.j.)
Auteur(s)
Mwaturura T., Bourne R.
ISSN
1934-3418 (Electronic)
ISSN-L
1078-4519
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
38
Numéro
6
Pages
E101-E103
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 = 164, n3 = 178) and in two population-based samples (CoLaus, n4 = 5409; GIANT, n5 = 113809). In the discovery sample, TT carriers of rs7754794C>T had 1.08 kg/m2 (p = 0.04) lower BMI as compared to C-allele carriers. This observation was replicated in an independent psychiatric sample (-2.18 kg/m2; p = 0.009). The association of rs7754794C>T and BMI seemed stronger in subjects younger than 45 years (median of age). In the population-based sample, a moderate association was observed (-0.17 kg/m2; p = 0.02) among younger individuals (<45y). Interestingly, this association was totally driven by patients meeting lifetime criteria for atypical depression, i.e. major depressive episodes characterized by symptoms such as an increased appetite. Indeed, patients with atypical depression carrying rs7754794-TT had 1.17 kg/m2 (p = 0.04) lower BMI values as compared to C-allele carriers, the effect being stronger in younger individuals (-2.50 kg/m2; p = 0.03; interaction between rs7754794 and age: p-value = 0.08). This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression.
Mots-clé
Adolescent, Football, Fracture Healing, Humans, Male, Restraint, Physical, Shoulder Fractures/complications, Shoulder Fractures/diagnosis, Shoulder Pain/diagnosis, Shoulder Pain/etiology, Treatment Outcome
Pubmed
Création de la notice
23/10/2015 9:05
Dernière modification de la notice
20/08/2019 15:27
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