Cognitive Impairment and Basal Ganglia Functional Connectivity in Vascular Parkinsonism.

Details

Serval ID
serval:BIB_B99A68EA7940
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cognitive Impairment and Basal Ganglia Functional Connectivity in Vascular Parkinsonism.
Journal
AJNR. American journal of neuroradiology
Author(s)
Dunet V., Deverdun J., Charroud C., Le Bars E., Molino F., Menjot de Champfleur S., Maury F., Charif M., Ayrignac X., Labauge P., Castelnovo G., Pinna F., Bonafe A., Geny C., Menjot de Champfleur N.
ISSN
1936-959X (Electronic)
ISSN-L
0195-6108
Publication state
Published
Issued date
12/2016
Peer-reviewed
Oui
Volume
37
Number
12
Pages
2310-2316
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Patients with vascular parkinsonism have higher cognitive decline and more basal ganglia lesions. We aimed to evaluate the relationship of cognitive impairment with functional connectivity between the basal ganglia and cingulate cortex in vascular parkinsonism.
Thirty patients (8 with vascular parkinsonism and 22 with Parkinson disease) and 23 controls were enrolled. The Mattis Dementia Rating Scale and the Stroop Task were used to assess cognitive decline. MR imaging examinations included T1-MPRAGE, FLAIR, and resting-state fMRI sequences. MPRAGE was segmented to obtain basal ganglia and cingulate cortex volumes. FLAIR was segmented to obtain white matter hyperintensity lesion volume. Resting-state fMRI sequences were used to compare basal ganglia functional connectivity with the cingulate cortex between patients and controls.
Patients with vascular parkinsonism exhibited impaired attention, resistance to interference, and inhibitory control and an increased number of errors on the Stroop Task. They also had higher caudate nucleus and white matter hyperintensity lesion volumes, which were positively correlated (ρ = 0.75, P < .0001). Caudate nucleus functional connectivity with the perigenual anterior cingulate cortex was increased in patients with vascular parkinsonism compared with controls and patients with Parkinson disease, and it was positively correlated with the caudate nucleus volume (ρ = 0.44, P = .016). Caudate nucleus functional connectivity with the posterior cingulate cortex was decreased in patients with vascular parkinsonism compared with controls and negatively correlated with the number of errors on the Stroop test (ρ = -0.51, P = .0003).
In patients with vascular parkinsonism, cognitive decline could be related to changes of caudate nucleus functional connectivity with the cingulate cortex at resting-state, which may be induced by ischemia-related remodelling.

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Create date
25/07/2016 17:34
Last modification date
20/08/2019 16:27
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