Effect of alpha-glycohydrolase inhibitors (Bay m1099 and Bay o1248) on sucrose metabolism in normal men

Details

Serval ID
serval:BIB_B96F033E446A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of alpha-glycohydrolase inhibitors (Bay m1099 and Bay o1248) on sucrose metabolism in normal men
Journal
Metabolism: Clinical and Experimental
Author(s)
Cauderay  M., Tappy  L., Temler  E., Jequier  E., Hillebrand  I., Felber  J. P.
ISSN
0026-0495 (Print)
Publication state
Published
Issued date
05/1986
Volume
35
Number
5
Pages
472-7
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article --- Old month value: May
Abstract
The inhibitory effect of N- beta-(4-ethoxycarbonylphenoxy-ethyl-1-desoxynojirimycin (BAY o1248) and of N-hydroxyethyl-1-desoxynojirimycin (BAY o1099) was studied in normal men. Nine healthy volunteers (weight range of 82% to 117% of their ideal body weight) ingested a 50 g sucrose load together with placebo, 50 mg BAY m1099, or 10 mg BAY of o1248. Their substrate oxidation rate was measured by continuous indirect calorimetry during four hours. The plasma glucose and plasma insulin peaks were both significantly blunted and the late fall of glycemia reduced. Mean plasma glucose, fructose, and insulin were reduced by both drugs during the first two hours following the sucrose load and led to a decrease of the suprabasal glucose oxidation (oxidation above baseline) during the first two hours of the test. However, the total suprabasal glucose oxidation during the four hours of the test was not significantly different from that of the control. Breath hydrogen, as an index of malabsorption, was shown to increase with both 50 mg BAY m1099 and 10 mg BAY o1248, starting from the third hour. These findings are consistent with a significant delay of sucrose absorption induced by these new alpha-glycohydrolase inhibitors.
Keywords
Administration, Oral Adult Blood Glucose/metabolism Breath Tests Fatty Acids, Nonesterified/blood Glucosamine/analogs & derivatives/pharmacology Humans Hydrogen/metabolism Imino Pyranoses Insulin/blood Lipids/blood Male Pulmonary Gas Exchange/drug effects Sucrose/*metabolism
Pubmed
Web of science
Create date
24/01/2008 13:36
Last modification date
20/08/2019 15:27
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