New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_B96DE13CC3A4
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
New opportunities in vasopressin and oxytocin research: a perspective from the amygdala.
Périodique
Annual Review of Neuroscience
Auteur(s)
Stoop R., Hegoburu C., van den Burg E.
ISSN
1545-4126 (Electronic)
ISSN-L
0147-006X
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
38
Pages
369-388
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
In the present review, we discuss how the evolution of oxytocin and vasopressin from a single ancestor peptide after gene duplication has stimulated the development of the vertebrate social brain. Separate production sites became possible with a hypothalamic development, which, interestingly, is triggered by the same transcription factors that underlie the development of various subcortical regions where vasopressin and oxytocin receptors are adjacently expressed and which are connected by inhibitory circuits. The opposite modulation of their output by vasopressin and oxytocin could thus create a dynamic equilibrium for rapid responsiveness to external stimuli. At the level of the individual, nurturing early in life can long-lastingly program oxytocin signaling, maintaining a capability of learning and sensitivity to external stimuli that contributes to development of social behavior in adulthood. Oxytocin and vasopressin are thus important for the development of a vertebrate brain that supports bonding between individuals and building of an interactive community.
Mots-clé
Amygdala/metabolism, Amygdala/physiology, Animals, Brain/growth & development, Epigenesis, Genetic/genetics, Epigenesis, Genetic/physiology, Humans, Oxytocin/genetics, Oxytocin/metabolism, Receptors, Oxytocin/metabolism, Receptors, Vasopressin/metabolism, Social Behavior, Vasopressins/genetics, Vasopressins/metabolism
Pubmed
Web of science
Création de la notice
24/08/2015 16:55
Dernière modification de la notice
20/08/2019 15:27
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