Determination of urinary catecholamines and metanephrines in cardiac deaths.

Détails

ID Serval
serval:BIB_B91AE83B07BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Determination of urinary catecholamines and metanephrines in cardiac deaths.
Périodique
International journal of legal medicine
Auteur(s)
Hervet T., Grouzmann E., Grabherr S., Mangin P., Palmiere C.
ISSN
1437-1596 (Electronic)
ISSN-L
0937-9827
Statut éditorial
Publié
Date de publication
07/2016
Peer-reviewed
Oui
Volume
130
Numéro
4
Pages
995-1001
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The aim of this study was to measure catecholamines and their O-methylated metabolites in urine and vitreous humor collected in cardiac deaths and noncardiac control cases that underwent medicolegal investigations. Our first goal was to assess whether cardiac events of different types are characterized by different catecholamine/metanephrine urine and/or vitreous profiles. Our second goal was to determine whether noncardiac causes of death with different survival intervals are characterized by different catecholamine/metanephrine urine and/or vitreous profiles. Two study groups were prospectively and retrospectively formed, a cardiac death group (including three subgroups, according to the cause of death) and a noncardiac death group (including two subgroups, according to the length of the agonal period). Postmortem angiography, autopsy, histology, toxicology, and biochemistry were performed in all cases. First results seem to indicate that absolute values measured in urine and vitreous for each of the analyzed markers display no significant differences relating to each of the tested cardiac death subgroups. In the control group, absolute concentrations measured in urine and vitreous for each of the analyzed parameters failed to show significant differences relating to the length of agonal period. Our preliminary findings do not seem to confirm the conclusions of former studies and fail to corroborate the usefulness of urine catecholamine and metanephrine analysis to characterize stress response intensity or length of the dying process in the postmortem setting.

Mots-clé
Adolescent, Adult, Aged, Case-Control Studies, Catecholamines/urine, Death, Dopamine/analogs & derivatives, Dopamine/urine, Female, Forensic Pathology, Heart Diseases/urine, Humans, Male, Middle Aged, Vitreous Body/chemistry, Young Adult, Cardiac death, Catecholamines, Metanephrines, Postmortem biochemistry, Urine, Vitreous humor
Pubmed
Web of science
Création de la notice
30/12/2015 9:35
Dernière modification de la notice
20/08/2019 16:27
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