Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription.

Détails

ID Serval
serval:BIB_B909C7A435AF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Small nuclear RNA genes: a model system to study fundamental mechanisms of transcription.
Périodique
Journal of Biological Chemistry
Auteur(s)
Hernandez N.
ISSN
0021-9258[print], 0021-9258[linking]
Statut éditorial
Publié
Date de publication
2001
Volume
276
Numéro
29
Pages
26733-26736
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review Publication Status: ppublish
Résumé
The human small nuclear RNA (snRNA)1 genes, which encode snRNAs that are involved in RNA processing reactions such as mRNA splicing, serve as prototypes for a family of genes whose promoters are characterized by the presence of a proximal sequence element (PSE) and a distal sequence element (DSE). From a transcription point of view, this family of genes is highly interesting because all of its members have very similar promoters, even though some of them are transcribed by RNA polymerase (pol) II and others by pol III. As a result, the snRNA genes have served as a model system to explore how RNA polymerase specificity is determined and, in general, to compare the pol II and III transcription machineries. This has led to the concept that the pol II and III transcription machineries use common factors, the best known of which is the TATA box binding protein (TBP). In addition, the relative simplicity of these promoters has also made them an attractive system to study how transcriptional activators perform their function.
Mots-clé
Animals, DNA Polymerase III/metabolism, Humans, Promoter Regions, Genetic, RNA, Small Nuclear/genetics, Trans-Activators/metabolism, Transcription, Genetic
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/01/2008 17:34
Dernière modification de la notice
20/08/2019 16:27
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