Kinase signaling cascades that modulate peroxisome proliferator-activated receptors.

Details

Serval ID
serval:BIB_B8BBADFB7D53
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Kinase signaling cascades that modulate peroxisome proliferator-activated receptors.
Journal
Current Opinion in Cell Biology
Author(s)
Gelman L., Michalik L., Desvergne B., Wahli W.
ISSN
0955-0674[print], 0955-0674[linking]
Publication state
Published
Issued date
2005
Peer-reviewed
Oui
Volume
17
Number
2
Pages
216-222
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in lipid and glucose homeostasis, inflammation and wound healing. In addition to ligand binding, phosphorylation can also regulate PPARs; the biological effects of phosphorylation depend on the stimulus, the kinase, the PPAR isotype, the residue modified, the cell type and the promoter investigated. The study of this dual regulation mode, which allows PPARs to integrate signals conveyed by lipophilic ligands with those coming from the plasma membrane, may ultimately offer new therapeutic strategies.
Keywords
Animals, Cell Nucleus/metabolism, Energy Metabolism/physiology, Humans, Intracellular Signaling Peptides and Proteins/metabolism, Peroxisome Proliferator-Activated Receptors/metabolism, Phosphorylation, Phosphotransferases/metabolism, Signal Transduction/physiology, Transcriptional Activation/physiology
Pubmed
Web of science
Create date
24/01/2008 15:26
Last modification date
20/08/2019 15:26
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