Monitoring of aglycons of yew glycosides (3,5-dimethoxyphenol, myrtenol and 1-octen-3-ol) as first indicator of yew presence.

Détails

ID Serval
serval:BIB_B887A8F00E0E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Monitoring of aglycons of yew glycosides (3,5-dimethoxyphenol, myrtenol and 1-octen-3-ol) as first indicator of yew presence.
Périodique
Drug Testing and Analysis
Auteur(s)
Varlet V., Augsburger M.
ISSN
1942-7611 (Electronic)
Statut éditorial
Publié
Date de publication
2013
Volume
5
Numéro
6
Pages
474-479
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
The toxicity of yew (Taxus spp) is well known from ancient times and is mainly due to taxins acting as inhibitors of calcium and sodium transport across the cell membrane of cardiac myocytes. The confirmation of yew taxins in body fluids can be carried out by liquid chromatography-tandem mass spectrometry (LC-MS/MS). However, before selecting this precise but expensive technique, an orientation test should be done to ascertain yew presence as toxic agent in the organism. As the 3,5-dimethoxyphenol (3,5-DMP), myrtenol and 1-octen-3-ol appear as glycosidically bound volatile compounds and are very yew specific, the detection of 3,5-DMP and the measurement of 1-octen-3-ol / myrtenol concentration ratio constitute reliable indicators of yew presence in forensic cases. The detection of these compounds is easily performed by gas chromatography-mass spectrometry (GC-MS) (SIM) after an enzymatic hydrolysis (β-glucosidase) allowing the release of volatile compounds from yew glycosides. Copyright © 2012 John Wiley & Sons, Ltd.
Mots-clé
yew, aglycons, 3,5-dimethoxyphenol, myrtenol, 1-octen-3-ol
Pubmed
Web of science
Création de la notice
26/07/2013 16:40
Dernière modification de la notice
20/08/2019 15:26
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