Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Le remplissage vasculaire au cours du choc septique. [Volume expansion during septic shock]
Bulletin de l'Academie Nationale de Médecine
1621-9; discussion 1629-30
At its very early phase, septic shock is characterized by severe hypovolemia related to abundant fluid losses, increased venous compliance and maldistribution of extracellular fluid (interstitial edema, splanchnic pooling). It results in a drop in venous return and cardiac output. Volume expansion, with crystalloids or colloids produces a hyperdynamic state with high cardiac output and low peripheral resistances. The quantity of liquid administered rather than its composition is the main determinant. Clinical examination and hemodynamic monitoring (Swan-Ganz catheter) appear to provide the most useful criteria to assess the limits of liquid administration. Better understanding in the mechanisms of circulatory dysfunction due to the inflammation cascades might soon lead to a new approach in fluid therapy.
Blood Volume/drug effects Cardiac Output Catheterization, Swan-Ganz/instrumentation/methods Colloids/*therapeutic use Fluid Therapy/*methods Hemodynamic Processes Humans Hypovolemia/diagnosis/*microbiology/physiopathology/*therapy Inflammation Isotonic Solutions Monitoring, Physiologic/instrumentation/methods Physical Examination/methods Plasma Substitutes/pharmacology/*therapeutic use Rehydration Solutions/*therapeutic use Shock, Septic/*complications/immunology Vascular Resistance
Web of science
Last modification date