Essential role of CCL21 in establishment of central self-tolerance in T cells.

Détails

Ressource 1Télécharger: 1925.full.pdf (2365.85 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_B84853723C4B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Essential role of CCL21 in establishment of central self-tolerance in T cells.
Périodique
Journal of Experimental Medicine
Auteur(s)
Kozai M., Kubo Y., Katakai T., Kondo H., Kiyonari H., Schaeuble K., Luther S.A., Ishimaru N., Ohigashi I., Takahama Y.
ISSN
1540-9538 (Electronic)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
214
Numéro
7
Pages
1925-1935
Langue
anglais
Résumé
The chemokine receptor CCR7 directs T cell relocation into and within lymphoid organs, including the migration of developing thymocytes into the thymic medulla. However, how three functional CCR7 ligands in mouse, CCL19, CCL21Ser, and CCL21Leu, divide their roles in immune organs is unclear. By producing mice specifically deficient in CCL21Ser, we show that CCL21Ser is essential for the accumulation of positively selected thymocytes in the thymic medulla. CCL21Ser-deficient mice were impaired in the medullary deletion of self-reactive thymocytes and developed autoimmune dacryoadenitis. T cell accumulation in the lymph nodes was also defective. These results indicate a nonredundant role of CCL21Ser in the establishment of self-tolerance in T cells in the thymic medulla, and reveal a functional inequality among CCR7 ligands in vivo.

Pubmed
Web of science
Open Access
Oui
Création de la notice
22/06/2017 16:27
Dernière modification de la notice
20/08/2019 15:26
Données d'usage