Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?

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State: Public
Version: Final published version
Serval ID
serval:BIB_B8381B054675
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?
Journal
Aging
Author(s)
Gachon F., Bonnefont X.
ISSN
1945-4589[electronic], 1945-4589[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
2
Number
2
Pages
101-106
Language
english
Abstract
By regulating the metabolism of fatty acids, carbohydrates, and xenobiotic, the mammalian circadian clock plays a fundamental role on the liver physiology. At present, it is supposed that the circadian clock regulates metabolism mostly by regulating the expression of liver enzymes at the transcriptional level. However, recent evidences suggest that some signaling pathways synchronized by the circadian clock can also influence metabolism at a post-transcriptional level. In this context, we have recently shown that the circadian clock synchronizes the rhythmic activation of the IRE1alpha pathway in the endoplasmic reticulum. The absence of circadian clock perturbs this secondary clock, provokes deregulation of endoplasmic reticulum-localized enzymes, and leads to impaired lipid metabolism. We will describe here the additional pathways synchronized by the clock and discussed the influence of the circadian clock-controlled feeding rhythm on them.
Pubmed
Web of science
Create date
24/03/2010 16:24
Last modification date
20/10/2020 14:41
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